By Sandra Smith, Geralyn Frandsen
This renowned center nursing pharmacology textbook offers certain insurance of nursing interventions for drug remedy with similar rationales. hugely praised for its prepared and readable presentation, the textual content explains the "why" at the back of every one nursing motion, and emphasizes how medicinal drugs paintings another way in several sufferers. The tenth version has a brand new clean layout and process with an further specialise in sufferer security built-in into the textual content.
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Extra info for Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (10th Edition)
You plan to measure her blood pressure to check that it is within normal limits (for Mrs. Green), as well as assess her understanding of her antihypertensive medications and dosing regimen. indd 16 11/27/2012 12:01:26 PM CHAPTER 2 17 Basic Concepts and Processes Antagonist: drug that inhibits cell function by occupying receptor sites Antidote: substance that relieves, prevents, or counteracts the effect of a poison Bioavailability: portion of a drug dose that reaches the systemic circulation and is available to act on body cells Biotransformation: when drugs are altered from their original form into a new form by the body; also referred to as metabolism Distribution: transport of drug molecules within the body; after a drug is injected or absorbed into the bloodstream, it is carried by the blood and tissue fluids to its sites of action, metabolism, and excretion Enterohepatic recirculation: drugs or metabolites that are excreted in bile, reabsorbed from the small intestine, returned to the liver, metabolized, and eventually excreted in urine.
2 Entry and movement of drug molecules through the body to sites of action, metabolism, and excretion. Numerous factors affect the rate and extent of drug absorption, including dosage form, route of administration, blood flow to the site of administration, GI function, the presence of food or other drugs, and other variables. Dosage form is a major determinant of a drug’s bioavailability (the portion of a dose that Drug Transport Pathways and Mechanisms Pathways There are three main pathways of drug movement across cell membranes.
3 describe the transport pathways and mechanisms used to move drug molecules through the body. , “what the body does to the drug”) to reach sites of action, metabolism, and excretion. Specific processes are absorption, distribution, metabolism, and excretion. Metabolism and excretion are often grouped together as drug elimination or clearance mechanisms. Overall, these processes largely determine serum drug levels; onset, peak, and duration of drug actions; therapeutic and adverse effects; and other important aspects of drug therapy.